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Article

Variable histone modifications at the A(vy) metastable epiallele.

Epigenetics - 1 Oct 2010

Dolinoy Dana C, Weinhouse Caren, Jones Tamara R, Rozek Laura S, Jirtle Randy L

Abstract excerpt

The ability of environmental factors to shape health and disease involves epigenetic mechanisms that mediate gene-environment interactions. Metastable epiallele genes are variably expressed in genetically identical individuals due to epigenetic modifications established during early development. DNA methylation within metastable epialleles is stochastic due to probabilistic reprogramming of epigenetic marks...

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Identifiers

PMID: 20671424
DOI: 10.4161/epi.5.7.12892
PMCID: PMC3052847

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Source receipt: pubmed, retrieved 7 Sept 2026.

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