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Mouse metastable epialleles are extremely rare.

Nucleic acids research - 19 Jul 2025

Gunasekara Chathura J, Maduranga Uditha, Zhang Taylor, Wells Jonathan N, Baker Maria S, Laritsky Eleonora, Li Yumei, Coarfa Cristian, Zhu Yi, Waterland Robert A

Abstract excerpt

Metastable epialleles (MEs) are genomic loci at which epigenetic marks are established stochastically during early embryonic development and maintained during subsequent differentiation and throughout life, leading to stable epigenetic and phenotypic variation among genetically identical individuals. Although MEs were first described in mice over 20 years ago, the extent of epigenetic metastability in the mouse...

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PMID: 40694849
DOI: 10.1093/nar/gkaf624
PMCID: PMC12282951

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