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Article

Variably methylated retrotransposons are refractory to a range of environmental perturbations.

Nature genetics - 1 Aug 2021

Bertozzi Tessa M, Becker Jessica L, Blake Georgina E T, Bansal Amita, Nguyen Duy K, Fernandez-Twinn Denise S, Ozanne Susan E, Bartolomei Marisa S, Simmons Rebecca A, Watson Erica D, Ferguson-Smith Anne C

Abstract excerpt

The agouti viable yellow (Avy) allele is an insertional mutation in the mouse genome caused by a variably methylated intracisternal A particle (VM-IAP) retrotransposon. Avy expressivity is sensitive to a range of early-life chemical exposures and nutritional interventions, suggesting that environmental perturbations can have long-lasting effects on the methylome. However, the extent to which VM-IAP elements are...

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Identifiers

PMID: 34326545
DOI: 10.1038/s41588-021-00898-9
PMCID: PMC7611517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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