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Article

Metastable epialleles in humans.

Trends in genetics : TIG - 1 Jan 2024

Derakhshan Maria, Kessler Noah J, Hellenthal Garrett, Silver Matt J

Abstract excerpt

First identified in isogenic mice, metastable epialleles (MEs) are loci where the extent of DNA methylation (DNAm) is variable between individuals but correlates across tissues derived from different germ layers within a given individual. This property, termed systemic interindividual variation (SIV), is attributed to stochastic methylation establishment before germ layer differentiation. Evidence suggests that...

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PMID: 38000919
DOI: 10.1016/j.tig.2023.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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