An expression microarray approach for the identification of metastable epialleles in the mouse genome.

doi:10.4161/epi.6.9.17103

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Article

An expression microarray approach for the identification of metastable epialleles in the mouse genome.

Epigenetics - 1 Sept 2011

Weinhouse Caren, Anderson Olivia S, Jones Tamara R, Kim Jung, Liberman Shayna A, Nahar Muna S, Rozek Laura S, Jirtle Randy L, Dolinoy Dana C

Abstract excerpt

Genetic loci displaying environmentally responsive epigenetic marks, termed metastable epialleles, offer a solution to the paradox presented by genetically identical yet phenotypically distinct individuals. The murine viable yellow agouti (A (vy) ) metastable epiallele exhibits stochastic DNA methylation and histone modifications associated with coat color variation in isogenic individuals. The distribution of A...

Topics

Alleles
Animals
Benzhydryl Compounds
Brain
CpG Islands
DNA Methylation
Diet
Genetic Loci
Genome
Genomic Instability
HSP40 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Liver

Male

Mice

Mice, Inbred C3H

Oligonucleotide Array Sequence Analysis

Phenols

Source

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Identifiers

PMID: 21829099
DOI: 10.4161/epi.6.9.17103
PMCID: PMC3225746

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