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Article

CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation.

PloS one - 4 Feb 2010

Cropley Jennifer E, Suter Catherine M, Beckman Kenneth B, Martin David I K

Abstract excerpt

BACKGROUND: The viable yellow allele of agouti (A(vy)) is remarkable for its unstable and partially heritable epigenetic state, which produces wide variation in phenotypes of isogenic mice. In the A(vy) allele an inserted intracisternal A particle (IAP) acts as a controlling element which deregulates expression of agouti by transcription from the LTR of the IAP; the phenotypic state has been linked to CpG...

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Identifiers

PMID: 20140227
DOI: 10.1371/journal.pone.0009055
PMCID: PMC2816220

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