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Article

The genetics of type I interferon in systemic lupus erythematosus.

Current opinion in immunology - 1 Oct 2012

Bronson Paola G, Chaivorapol Christina, Ortmann Ward, Behrens Timothy W, Graham Robert R

Abstract excerpt

The discovery that type I interferon (IFN)-inducible genes were strongly upregulated in peripheral blood in SLE over a decade ago sparked interest in understanding the relationship between type I IFN and SLE. Genome-wide association studies provide strong genetic evidence that type I IFNs are important for SLE risk. Of 47 genetic variants associated with SLE, over half (27/47, 57%) can be linked to type I IFN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22889593
DOI: 10.1016/j.coi.2012.07.008

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