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Article

Genetic Polymorphisms in Systemic Lupus Erythematosus and Their Clinical Implications: A Narrative Review.

International journal of molecular sciences - 29 Apr 2026

Egan Audrey Matilda, Johdi Nor Adzimah, Azizan Elena Aisha, Mohd Rozita, Rajalingham Sakthiswary, Shaharir Syahrul Sazliyana, Zailani Mohamed Afiq Hidayat

Abstract excerpt

Systemic lupus erythematosus (SLE) is a polygenic autoimmune disorder where genetic diversity drives significant clinical heterogeneity. This review summarizes the current understanding of the roles of genetic polymorphisms in immunological dysregulation, organ-specific manifestations and therapeutic response heterogeneity in individuals with SLE. The literature was obtained from PubMed, EBSCOhost, Web of Science...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42123548
DOI: 10.3390/ijms27093968
PMCID: PMC13164053

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STAT4
FBN2
TLR7

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