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Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond

30 Sept 2019

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology that primarily affects women of childbearing age. The development of SLE is attributed to the breach of immunological tolerance and the interaction between SLE-susceptibility genes and various environmental factors, resulting in the production of pathogenic autoantibodies. Working in concert with the innate and adaptive arms of...

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PMID: 31575058
DOI: 10.3390/cells8101180

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