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Article

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010

Cole David K, Edwards Emily S J, Wynn Katherine K, Clement Mathew, Miles John J, Ladell Kristin, Ekeruche Julia, Gostick Emma, Adams Katherine J, Skowera Ania, Peakman Mark, Wooldridge Linda, Price David A, Sewell Andrew K

Abstract excerpt

Improving T cell Ags by altering MHC anchor residues is a common strategy used to enhance peptide vaccines, but there has been little assessment of how such modifications affect TCR binding and T cell recognition. In this study, we use surface plasmon resonance and peptide-MHC tetramer binding at the cell surface to demonstrate that changes in primary peptide anchor residues can substantially and unpredictably...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20639478
DOI: 10.4049/jimmunol.1000629
PMCID: PMC3024538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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