Article
MHC class I-peptide interactions and TCR recognition.
Cancer surveys - 1 Jan 1995
Young A C, Zhang W, Sacchettini J C, Nathenson S G
Abstract excerpt
The recent crystal structure determinations of MHC class I molecules with single bound peptides have allowed us to understand the guidelines that govern peptide binding in a given MHC allele. Evolution has provided for MHC class I molecules whose antigen binding clefts possess distinct physical a...
Topics
- Alleles
- Animals
- Binding Sites
- Epitopes
- Genes, MHC Class I
- Histocompatibility Antigens Class I
- Humans
- Immunity, Cellular
- Mice
- Molecular Structure
- Peptides
- Receptors, Antigen, T-Cell
- T-Lymphocytes