Article
MHC class I-peptide interactions and TCR recognition.
Cancer surveys - 1 Jan 1995
Young A C, Zhang W, Sacchettini J C, Nathenson S G
Abstract excerpt
The recent crystal structure determinations of MHC class I molecules with single bound peptides have allowed us to understand the guidelines that govern peptide binding in a given MHC allele. Evolution has provided for MHC class I molecules whose antigen binding clefts possess distinct physical and chemical properties as a result of the particular arrangement of variable residues lining the binding cleft. As a...
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