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Article

Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes.

Immunology - 1 Jun 2012

Hsu Shiou-Chih, Chang Chih-Peng, Tsai Chao-Yuan, Hsieh Shih-Hung, Wu-Hsieh Betty A, Lo Yu-Shu, Yang Jinn-Moon

Abstract excerpt

MHC class I-restricted CD8 T-lymphocyte epitopes comprise anchor motifs, T-cell receptor (TCR) contact residues and the peptide backbone. Serial variant epitopes with substitution of amino acids at either anchor motifs or TCR contact residues have been synthesized for specific interferon-γ responses to clarify the TCR recognition mechanism as well as to assess the epitope prediction capacity of immunoinformatical...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22121944
DOI: 10.1111/j.1365-2567.2011.03542.x
PMCID: PMC3403262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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