Article
Effect of secondary anchor amino acid substitutions on the immunogenic properties of an HLA-A*0201-restricted T cell epitope derived from the Trypanosoma cruzi KMP-11 protein.
Peptides - 1 Apr 2016
Lasso Paola, Cárdenas Constanza, Guzmán Fanny, Rosas Fernando, Thomas María Carmen, López Manuel Carlos, González John Mario, Cuéllar Adriana, Campanera Josep Maria, Luque F Javier, Puerta Concepción Judith
Abstract excerpt
The TcTLE peptide (TLEEFSAKL) is a CD8(+) T cell HLA-A*0201-restricted epitope derived from the Trypanosoma cruzi KMP-11 protein that is efficiently processed, presented and recognized by CD8(+) T cells from chagasic patients. Since the immunogenic properties of wild-type epitopes may be enhanced by suitable substitutions in secondary anchor residues, we have studied the effect of introducing specific mutations...
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