Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide.

doi:10.1111/j.1365-2567.2006.02434.x

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Article

Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide.

Immunology - 1 Nov 2006

Lazoura Eliada, Lodding Jodie, Farrugia William, Ramsland Paul A, Stevens James, Wilson Ian A, Pietersz Geoffrey A, Apostolopoulos Vasso

Abstract excerpt

Designing peptide-based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide-MHC complex and the T-cell receptor. Past efforts to immunize with high-affinity tumour-associated antigenic peptides have not been very immunogenic, which may be...

Topics

Animals
Antigens, Neoplasm
Cancer Vaccines
Cell Line
Crystallography, X-Ray
Drosophila melanogaster
H-2 Antigens
Histocompatibility Antigens Class I
Immunity, Cellular
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Models, Molecular

Mucin-1

Mutation

Peptide Fragments

Protein Binding

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 17067310
DOI: 10.1111/j.1365-2567.2006.02434.x
PMCID: PMC1819580

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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