Article

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

2019-12-02

Abstract excerpt

Viral escape from CD8 + cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that CD8 + T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune escape variant Y4F is restored following vaccination with a proline-altered peptide ligand (APL). The APL increases MHC/peptide (pMHC) complex stabi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a95b348b-e077-5f68-845c-f54f3942b9ca
DOI: 10.1101/862144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccinationDOI 10.1101/862144Read

A biophysical framework for accurately identifying antigen single-amino acid escape variants and corresponding variant-specific compensatory TCR sequencesSemantic proximity Read

Immunotherapy: Nice to see you - evolving MHC I-peptide presentation.Semantic proximity Read

Enhanced T cell receptor specificity through framework engineering.Semantic proximity Read

A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.Semantic proximity Read

Altered peptide ligand design: altering immune responses to class I MHC/peptide complexes.Semantic proximity Read

MHC class I-peptide interactions and TCR recognition.Semantic proximity Read

A dual-arm peptide vaccine against KRAS, EGFR, PD-L1 and VEGFR2 for non-small cell lung cancer in Vietnamese patientsSemantic proximity Read

Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Semantic proximity Read

Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses.Semantic proximity Read

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read

The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I DimerizationSemantic proximity Read

Mapping the Modification Landscape of MHC-I Epitopes: A Framework for Immunogenic Peptidomimetic Antigen DesignSemantic proximity Read