Article
Recognition of allo-peptide is governed by novel anchor imposition and limited variations in TCR contact residues.
Molecular immunology - 1 Mar 2008
Reinbold Corbett J A, Malarkannan Subramaniam
Abstract excerpt
Immune specificity of a T cell is determined by the TCR contact residues exposed on the antigenic peptide/MHC complex. Naturally processed, biallelic epitopes from H7 minor histocompatibility (mH) antigen vary in position 7 (p7) from aspartic acid (D) to a glutamic acid (E), which differ by an additional methylene (-CH(2)) in the side chain. Here, we show that this variation generates a strong anti-H7a or...
Topics
- Amino Acid Substitution
- Animals
- Binding Sites
- Cell Line
- Epitopes, T-Lymphocyte
- Genetic Variation
- Mice
- Mice, Inbred BALB C
- Minor Histocompatibility Antigens
- Mutation, Missense
- Peptides
- Receptors, Antigen, T-Cell
- T-Cell Antigen Receptor Specificity