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Effects of HLA single chain trimer design on peptide presentation and stability

3 May 2023

Abstract excerpt

MHC class I “single-chain trimer” molecules, coupling MHC heavy chain, β2-microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design that may affect its use for basic and translational studies, we evaluated a set of engineered single-chain trimers with combinations of stabilizing mutations across eight different...

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Identifiers

PMID: 37207206
DOI: 10.3389/fimmu.2023.1170462

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