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Article

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.

Immunology and cell biology - 1 Jan 2017

Dockree Tamsin, Holland Christopher J, Clement Mathew, Ladell Kristin, McLaren James E, van den Berg Hugo A, Gostick Emma, L Miners Kelly, Llewellyn-Lacey Sian, Bridgeman John S, Man Stephen, Bailey Mick, Burrows Scott R, Price David A, Wooldridge Linda

Abstract excerpt

The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of the pMHCI/CD8 interaction (~1.5-fold) can disproportionately amplify this effect, boosting antigen...

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Share to CD8 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27670790
DOI: 10.1038/icb.2016.85
PMCID: PMC5215125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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