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T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation

28 Jun 2019

Abstract excerpt

Adoptive transfer of T-cell-receptor (TCR)-transduced T cells has shown promising results for cancer treatment, but has also produced severe immunotoxicities caused by on-target as well as off-target TCR recognition. Off-target toxicities are related to the ability of a single T cell to cross-recognize and respond to several different peptide-major histocompatibility complex (pMHC) antigens; a property that is...

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PMID: 35036898
DOI: 10.1016/j.iotech.2019.06.003

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