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Article

Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.

Virology - 30 Sept 2010

Mkhwanazi Nompumelelo, Thobakgale Christina F, van der Stok Mary, Reddy Shabashini, Mncube Zenele, Chonco Fundisiwe, Walker Bruce D, Altfeld Marcus, Goulder Philip J R, Ndung'u Thumbi

Abstract excerpt

HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality of immmunodominant HLA-B*57/B5801- and HLA-Cw*07-restricted CD8+ T cells occurring concurrently in nine study subjects assessing IFN-gamma, TNF-alpha, IL-2, MIP-1beta, and CD107a by flow...

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Share to CD4 Lymphocyte Count
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

Share to HLA-B Antigens

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Source

Open in PubMed Open full text

Identifiers

PMID: 20638093
DOI: 10.1016/j.virol.2010.06.002
PMCID: PMC2954365

Genes

CD4
MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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