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Article

Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.

Journal of virology - 1 Jul 2001

Day C L, Shea A K, Altfeld M A, Olson D P, Buchbinder S P, Hecht F M, Rosenberg E S, Walker B D, Kalams S A

Abstract excerpt

Cytotoxic T lymphocytes (CTL) target multiple epitopes in human immunodeficiency virus (HIV)-infected persons, and are thought to influence the viral set point. The extent to which HLA class I allele expression predicts the epitopes targeted has not been determined, nor have the relative contributions of responses restricted by different class I alleles within a given individual. In this study, we performed a...

Topics

Alleles
Chronic Disease
Epitopes, T-Lymphocyte
HIV Infections
HIV-1
HLA-A1 Antigen
HLA-A2 Antigen
HLA-B7 Antigen
Histocompatibility Antigens Class I
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Cytotoxic

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Identifiers

PMID: 11413294
DOI: 10.1128/JVI.75.14.6279-6291.2001
PMCID: PMC114350

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