Article
Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Journal of virology - 1 Jul 2001
Day C L, Shea A K, Altfeld M A, Olson D P, Buchbinder S P, Hecht F M, Rosenberg E S, Walker B D, Kalams S A
Abstract excerpt
Cytotoxic T lymphocytes (CTL) target multiple epitopes in human immunodeficiency virus (HIV)-infected persons, and are thought to influence the viral set point. The extent to which HLA class I allele expression predicts the epitopes targeted has not been determined, nor have the relative contributions of responses restricted by different class I alleles within a given individual. In this study, we performed a...
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