Article
Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents.
AIDS (London, England) - 30 Nov 2007
Bansal Anju, Yue Ling, Conway Joan, Yusim Karina, Tang Jianming, Kappes John, Kaslow Richard A, Wilson Craig M, Goepfert Paul A
Abstract excerpt
BACKGROUND: Differential protein targeting by HIV-specific CD8 T cells is associated with disparate plasma viral loads; however, it is unclear if the quality of these responses differs depending upon the specificity of the targeted epitopes. METHODS: We examined HIV-specific CD8 T-cell responses in HIV-infected adolescents carrying either an HLA class I allele associated with a favorable prognosis (HLA-B*57) or...
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