Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.

doi:10.4049/jimmunol.176.7.4094

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Article

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Bihl Florian, Frahm Nicole, Di Giammarino Loriana, Sidney John, John Mina, Yusim Karina, Woodberry Tonia, Sango Kaori, Hewitt Hannah S, Henry Leah, Linde Caitlyn H, Chisholm John V, Zaman Tauheed M, Pae Eunice, Mallal Simon, Walker Bruce D, Sette Alessandro, Korber Bette T, Heckerman David, Brander Christian

Abstract excerpt

Immunodominance is variably used to describe either the most frequently detectable response among tested individuals or the strongest response within a single individual, yet factors determining either inter- or intraindividual immunodominance are still poorly understood. More than 90 individuals were tested against 184 HIV- and 92 EBV-derived, previously defined CTL epitopes. The data show that HLA-B-restricted...

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PMID: 16547245
DOI: 10.4049/jimmunol.176.7.4094

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