Article
Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype.
Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2007
Harari Alexandre, Cellerai Cristina, Bellutti Enders Felicitas, Köstler Josef, Codarri Laura, Tapia Gonzalo, Boyman Onur, Castro Erika, Gaudieri Silvana, James Ian, John Mina, Wagner Ralf, Mallal Simon, Pantaleo Giuseppe
Abstract excerpt
We studied CD8 T cell responses against HIV-1, cytomegalovirus, Epstein-Barr virus, and influenza in 128 subjects and demonstrate that polyfunctional CD8 T cell responses, also including IL-2 production and Ag-specific proliferation, are predominantly driven by virus epitopes restricted by HLA-B alleles. Interestingly, these protective CD8 T cells are equipped with low-avidity T cell receptors (TCRs) for the...
Topics
- CD8-Positive T-Lymphocytes
- Cohort Studies
- Cytomegalovirus
- Genotype
- HIV Infections
- HIV-1
- HLA-A Antigens
- HLA-B Antigens
- Herpesvirus 4, Human
- Humans
- In Vitro Techniques
- Interleukin-2