Article
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.
PLoS medicine - 6 May 2008
Streeck Hendrik, Brumme Zabrina L, Anastario Michael, Cohen Kristin W, Jolin Jonathan S, Meier Angela, Brumme Chanson J, Rosenberg Eric S, Alter Galit, Allen Todd M, Walker Bruce D, Altfeld Marcus
Abstract excerpt
BACKGROUND: Virus-specific CD8(+) T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic antigen persistence. It has been suggested that virus-specific CD8(+) T cells with a "polyfunctional" profile, defined by the capacity to secrete multiple cytokines or chemokines, are most...
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