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Article

Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006

Horton Helen, Frank Ian, Baydo Ruth, Jalbert Emilie, Penn Justin, Wilson Sean, McNevin John P, McSweyn Matthew D, Lee Deborah, Huang Yunda, De Rosa Stephen C, McElrath M Juliana

Abstract excerpt

HIV-1-infected persons with HLA-B27 and -B57 alleles commonly remain healthy for decades without antiretroviral therapy. Properties of CD8+ T cells restricted by these alleles considered to confer disease protection in these individuals are elusive but important to understand and potentially elicit by vaccination. To address this, we compared CD8+ T cell function induced by HIV-1 immunogens and natural infection...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Gene Products, gag

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Source

Identifiers

PMID: 17082660
DOI: 10.4049/jimmunol.177.10.7406

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection.PMID 17082660Read ↗

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