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Article

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells

4 Aug 2020

Abstract excerpt

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity against human influenza viruses. Several universally-conserved CD8+ T-cell specificities that elicit prominent responses against human influenza A viruses (IAVs)...

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PMID: 32750095
DOI: 10.1371/journal.ppat.1008714

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