Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase.

The Journal of biological chemistry - 5 Jul 1991

Bame K J, Reddy R V, Esko J D

Abstract excerpt

The coordination of N-deacetylation and N-sulfation of heparan sulfate was examined in wild-type Chinese hamster ovary cells and mutant pgsE-606. This mutant expresses about 3-fold less N-sulfotransferase activity, which causes the proportion of N-sulfated GlcN residues in heparan sulfate to decline from 39 to 21% of total GlcN (Bame, K.J., and Esko, J.D. (1989) J. Biol. Chem. 264, 8059-8065). In this report, we...

Topics

Acetylation
Amidohydrolases
Animals
Cell Line
Chromatography, Ion Exchange
Cricetinae
Cricetulus
Female
Glycosaminoglycans
Heparitin Sulfate
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Sulfotransferases

Sulfurtransferases

Source

Identifiers

PMID: 2061321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2061321-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coupling of N-deacetylation and N-sulfation in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase.PMID 2061321Read ↗

Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase.Semantic proximity Read ↗

Sulphated and undersulphated heparan sulphate proteoglycans in a Chinese hamster ovary cell mutant defective in N-sulphotransferase.Semantic proximity Read ↗

The spacing of S-domains on HS glycosaminoglycans determines whether the chain is a substrate for intracellular heparanases.Semantic proximity Read ↗

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.Semantic proximity Read ↗

Heparan N-sulfatase: in vitro mutagenesis of potential N-glycosylation sites.Semantic proximity Read ↗

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.Semantic proximity Read ↗

Selective impairment of the synthesis of basic fibroblast growth factor binding domains of heparan sulphate in a COS cell mutant defective in N-sulphotransferase.Semantic proximity Read ↗

Genetic analysis of the heparan modification network in Caenorhabditis elegans.Semantic proximity Read ↗

A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis.Semantic proximity Read ↗

Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids.Semantic proximity Read ↗

Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes.Semantic proximity Read ↗

Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.