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Article

Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids.

The Journal of biological chemistry - 12 Sept 1997

Bai X, Bame K J, Habuchi H, Kimata K, Esko J D

Abstract excerpt

To study how the pattern of sulfation along a heparan sulfate chain affects its turnover, we examined heparan sulfate catabolism in wild-type Chinese hamster ovary cells and mutant pgsF-17, defective in 2-O-sulfation of uronic acid residues (Bai, X., and Esko, J. D. (1996) J. Biol. Chem. 271, 17711-17717). Heparan sulfate from the mutant contains normal amounts of 6-O-sulfated glucosamine residues and iduronic...

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PMID: 9287321
DOI: 10.1074/jbc.272.37.23172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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