Article
Turnover of heparan sulfate depends on 2-O-sulfation of uronic acids.
The Journal of biological chemistry - 12 Sept 1997
Bai X, Bame K J, Habuchi H, Kimata K, Esko J D
Abstract excerpt
To study how the pattern of sulfation along a heparan sulfate chain affects its turnover, we examined heparan sulfate catabolism in wild-type Chinese hamster ovary cells and mutant pgsF-17, defective in 2-O-sulfation of uronic acid residues (Bai, X., and Esko, J. D. (1996) J. Biol. Chem. 271, 17711-17717). Heparan sulfate from the mutant contains normal amounts of 6-O-sulfated glucosamine residues and iduronic...
Topics
- Animals
- CHO Cells
- Carbohydrate Sequence
- Cricetinae
- Disaccharides
- Glucuronates
- Glucuronic Acid
- Glucuronidase
- Glycoside Hydrolases
- Heparan Sulfate Proteoglycans
- Heparitin Sulfate
- Hexuronic Acids
- Iduronic Acid
- Molecular Sequence Data
- Mutation
- Oligosaccharides
- Proteoglycans
- Substrate Specificity