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Article

Sulphated and undersulphated heparan sulphate proteoglycans in a Chinese hamster ovary cell mutant defective in N-sulphotransferase.

The Biochemical journal - 1 Oct 1994

Bame K J, Zhang L, David G, Esko J D

Abstract excerpt

The Chinese hamster ovary cell mutant, pgsE-606, synthesizes undersulphated heparan sulphate glycosaminoglycans because of a deficiency in N-sulphotransferase activity [Bame and Esko (1989) J. Biol. Chem. 264, 8059-8065]. We compared the heparan sulphate proteoglycans synthesized by mutant and wild-type cells to determine what effect the undersulphation defect had on proteoglycan structure. The majority of...

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Identifiers

PMID: 7945269
DOI: 10.1042/bj3030081
PMCID: PMC1137560

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