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Article

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

The Journal of biological chemistry - 24 Nov 2006

Ledin Johan, Ringvall Maria, Thuveson Maria, Eriksson Inger, Wilén Maria, Kusche-Gullberg Marion, Forsberg Erik, Kjellén Lena

Abstract excerpt

Heparan sulfate (HS) proteoglycans influence embryonic development through interactions with growth factors and morphogens. The interactions depend on HS structure, which is largely determined during biosynthesis by Golgi enzymes. NDST (glucosaminyl N-deacetylase/N-sulfotransferase), responsible for HS N-sulfation, is a key enzyme directing further modifications including O-sulfation. To elucidate the roles of...

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Source

Identifiers

PMID: 16984905
DOI: 10.1074/jbc.M604113200

Genes

NDST1
NDST2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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