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Article

Biosynthesis of heparan sulfate. Coordination of polymer-modification reactions in a Chinese hamster ovary cell mutant defective in N-sulfotransferase.

The Journal of biological chemistry - 5 Jun 1991

Bame K J, Lidholt K, Lindahl U, Esko J D

Abstract excerpt

A previous study identified a Chinese hamster ovary cell mutant, pgsE-606, which is defective in the N-sulfotransferase that catalyzes one of the initial polymer-modification reactions in the biosynthesis of heparan sulfate (Bame, K. J., and Esko, J. D. (1989) J. Biol. Chem. 264, 8059-8065). The structure of heparan sulfate generated by these cells reflects a 3-5-fold reduction in enzyme activity. The mutant...

Topics

Animals
Chromatography, Ion Exchange
Chromatography, Paper
Cricetinae
Cricetulus
Disaccharides
Electrophoresis, Paper
Heparitin Sulfate
Mutation
Polymers
Sulfotransferases

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PMID: 2037581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2037581-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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