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Article

The spacing of S-domains on HS glycosaminoglycans determines whether the chain is a substrate for intracellular heparanases.

Glycobiology - 1 Jul 2000

Bame K J, Venkatesan I, Stelling H D, Tumova S

Abstract excerpt

Heparanases are mammalian endoglucuronidases that degrade heparan sulfate (HS) glycosaminoglycans to short 5-6 kDa pieces. In the Golgi, HS glycosaminoglycans are modified by a series of interdependent reactions which result in chains that have regions rich in N- and O-sulfate groups and iduronate residues (S-domains), separated by regions that are nearly devoid of sulfate. Structural analysis of the short HS...

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PMID: 10910975
DOI: 10.1093/glycob/10.7.715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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