Article
Genetic analysis of the heparan modification network in Caenorhabditis elegans.
The Journal of biological chemistry - 13 May 2011
Townley Robert A, Bülow Hannes E
Abstract excerpt
Heparan sulfates (HS) are highly modified sugar polymers in multicellular organisms that function in cell adhesion and cellular responses to protein signaling. Functionally distinct, cell type-dependent HS modification patterns arise as the result of a conserved network of enzymes that catalyze deacetylations, sulfations, and epimerizations in specific positions of the sugar residues. To understand the genetic...
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