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Article

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.

The Journal of biological chemistry - 8 Oct 2004

Holmborn Katarina, Ledin Johan, Smeds Emanuel, Eriksson Inger, Kusche-Gullberg Marion, Kjellén Lena

Abstract excerpt

Heparan sulfate structure differs significantly between various cell types and during different developmental stages. The diversity is created during biosynthesis by sulfotransferases, which add sulfate groups to the growing chain, and a C5-epimerase, which converts selected glucuronic acid residues to iduronic acid. All these modifications are believed to depend on initial glucosamine N-sulfation carried out by...

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Source

Identifiers

PMID: 15319440
DOI: 10.1074/jbc.C400373200

Genes

NDST1
NDST2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.PMID 15319440Read ↗

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