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Article

Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma.

Genes, chromosomes & cancer - 1 Sept 2010

Schmidt Annette, Schmitz Roland, Giefing Maciej, Martin-Subero Jose Ignacio, Gesk Stefan, Vater Inga, Massow Anne, Maggio Ewerton, Schneider Markus, Hansmann Martin-Leo, Siebert Reiner, Küppers Ralf

Abstract excerpt

Survival of the malignant Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) is dependent on constitutive activation of the nuclear factor kappaB (NF-kappaB) transcription factor. The deubiquitinating enzyme CYLD is a negative regulator of NF-kappaB and known to function as a tumor suppressor. To determine whether CYLD mutations play a role in cHL pathogenesis, we sequenced the gene in cHL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20607853
DOI: 10.1002/gcc.20789

Genes

CYLD
NFKBIA
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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