Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

doi:10.1002/ijc.24502

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Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

International journal of cancer - 15 Sept 2009

Lake Annette, Shield Lesley A, Cordano Pablo, Chui Daniel T Y, Osborne Julie, Crae Shauna, Wilson Katherine S, Tosi Sabrina, Knight Samantha J L, Gesk Stefan, Siebert Reiner, Hay Ron T, Jarrett Ruth F

Abstract excerpt

A consistent feature of the Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) is the constitutive activation of NF-kappaB transcription factors. In Epstein-Barr virus (EBV)-associated cases of cHL, expression of viral antigens most probably leads to NF-kappaB activation but for non-EBV-associated cases, the mechanism is not clear. Previous small studies have demonstrated deleterious...

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Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

Abstract excerpt

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