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Article

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.

The Journal of experimental medicine - 11 May 2009

Schmitz Roland, Hansmann Martin-Leo, Bohle Verena, Martin-Subero Jose Ignacio, Hartmann Sylvia, Mechtersheimer Gunhild, Klapper Wolfram, Vater Inga, Giefing Maciej, Gesk Stefan, Stanelle Jens, Siebert Reiner, Küppers Ralf

Abstract excerpt

Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor kappaB (NF-kappaB). NF-kappaB activation through various stimuli is negatively regulated by the zinc finger protein A20. To determine whether A20 contributes to the pathogenesis of cHL, we sequenced TNFAIP3, encoding A20, in HL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19380639
DOI: 10.1084/jem.20090528
PMCID: PMC2715030

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.PMID 19380639Read ↗

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