Article
Mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in Hodgkin lymphoma.
Pathology, research and practice - 1 Mar 2017
Etzel Barbara-Magdalena, Gerth Melanie, Chen Yuan, Wünsche Elisa, Facklam Tina, Beck James F, Guntinas-Lichius Orlando, Petersen Iver
Abstract excerpt
AIMS: Survival and proliferation of Hodgkin and Reed-Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (CHL), are dependent on constitutive activation of nuclear factor kB (NF-κB). A20, encoded by TNF alpha-induced protein 3 (TNFAIP3), one of the inhibitors of NF-kB, was found to be inactivated by deletions and/or point mutations in CHL. METHODS: TNFAIP3 mutations were examined in 37...
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