Article
Genetic instability in Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2002
Re D, Zander T, Diehl V, Wolf J
Abstract excerpt
Genetic instability is a characteristic feature of the malignant Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin's lymphoma and the lymphocytic and histiocytic (L&H) cells in lymphocyte predominant Hodgkin's lymphoma. Genetic instability can be classified into four major categories: distinct DNA mutations (microsatellite instability); numerical aberrations (chromosomal instability); structural...
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