Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing.

Leukemia - 1 Sept 2025

Rausch Tobias, Schäfer Hendrik, Bein Julia, Mölder Felix, Beeck Lilian Kara, Kölsch Bernd, Borchert Sabrina, Benes Vladimir, Halbsguth Teresa, Brunnberg Uta, Oellerich Thomas, Tousseyn Thomas, Ponzoni Maurilio, Köster Johannes, Hansmann Martin-Leo, Küppers Ralf, Hartmann Sylvia

Abstract excerpt

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare malignant lymphoma characterised by a few large tumour cells expressing B-cell antigens in an inflammatory background. T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is now considered to be closely related to NLPHL. Little is known about the mutational spectrum of the lymphoma cells in primary NLPHL and THRLBCL due to the rarity of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SOCS3 gene

Share to Hodgkin Disease

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mutation

Share to T-Lymphocytes

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 40670673
DOI: 10.1038/s41375-025-02679-3
PMCID: PMC12380620

Genes

BCL6
CD74
ITPKB
JUNB
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing.PMID 40670673Read ↗

Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphomaSemantic proximity Read ↗

Genetic risk and immune dysregulation of classic Hodgkin lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma: a multicentric studySemantic proximity Read ↗

Newly identified mechanisms in B-cell non-Hodgkin lymphomas uncovered by next-generation sequencing.Semantic proximity Read ↗

Genetic aberrations of signaling pathways in lymphomagenesis: revelations from next generation sequencing studies.Semantic proximity Read ↗

Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis.Semantic proximity Read ↗

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphomaSemantic proximity Read ↗

Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.Semantic proximity Read ↗

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma.Semantic proximity Read ↗

Novel Approaches in Molecular Characterization of Classical Hodgkin LymphomaSemantic proximity Read ↗

Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targetsSemantic proximity Read ↗

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.Semantic proximity Read ↗

Molecular biology of Hodgkin lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.