Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.

Haematologica - 1 Jan 2010

Schumacher Martin A, Schmitz Roland, Brune Verena, Tiacci Enrico, Döring Claudia, Hansmann Martin-Leo, Siebert Reiner, Küppers Ralf

Abstract excerpt

Nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) shows constitutive NF-kappaB activity in the malignant lymphocyte-predominant (LP) cells. Constitutive NF-kappaB activity also plays a central pathogenetic role in classical Hodgkin's lymphoma (cHL), where inactivating mutations in the NFK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hodgkin Disease
Share to I-kappa B Proteins
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes

Share to Lymphoma, Follicular

Share to NF-kappa B

Share to NF-KappaB Inhibitor alpha

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 19648161
DOI: 10.3324/haematol.2009.010157
PMCID: PMC2805741

Genes

NFKBIA
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19648161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.PMID 19648161Read ↗

Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing.Semantic proximity Read ↗

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.Semantic proximity Read ↗

Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis.Semantic proximity Read ↗

Molecular biology of Hodgkin lymphomaSemantic proximity Read ↗

Mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in Hodgkin lymphoma.Semantic proximity Read ↗

Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.Semantic proximity Read ↗

Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma.Semantic proximity Read ↗

NF-κB deregulation in Hodgkin lymphoma.Semantic proximity Read ↗

Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma.Semantic proximity Read ↗

Mutation analysis of NF-κB signal pathway-related genes in ocular MALT lymphoma.Semantic proximity Read ↗

Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.Semantic proximity Read ↗

High familial risk in nodular lymphocyte-predominant Hodgkin lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.