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Article

Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Mar 2014

Wu Wei, Zhu Huayuan, Fu Yuan, Shen Wenyi, Xu Jiadai, Miao Kourong, Hong Ming, Xu Wei, Liu Peng, Li Jianyong

Abstract excerpt

Loss of cylindromatosis gene (CYLD) expression has been observed in various cancers, including chronic lymphocytic leukemia (CLL). As a deubiquitination enzyme, CYLD regulates the proliferation, development and activation of lymphoid cells. Here we determined the CYLD mRNA expression by quantitative polymerase chain reaction (PCR) in 125 patients with CLL. CYLD was considerably down-regulated in CLL cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23725390
DOI: 10.3109/10428194.2013.809077

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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