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Article

Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.

British journal of haematology - 1 Jun 2012

Otto Claudia, Giefing Maciej, Massow Anne, Vater Inga, Gesk Stefan, Schlesner Matthias, Richter Julia, Klapper Wolfram, Hansmann Martin-Leo, Siebert Reiner, Küppers Ralf

Abstract excerpt

Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) show constitutive activation of nuclear factor (NF)-κB. Several genetic lesions contribute to this deregulated NF-κB activity. Here, we analysed two further NF-κB regulators for genetic lesions, the inhibitory factor TRAF3 and the key signalling component of the alternative NF-κB pathway, MAP3K14 (NIK). Single nucleotide polymorphism (SNP)...

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Source

Identifiers

PMID: 22469134
DOI: 10.1111/j.1365-2141.2012.09113.x

Genes

TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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