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Article

Focal Adhesion Kinase Is Required for Blood Vessel Morphogenesis

20 Feb 2003

Abstract excerpt

The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and mechanical stimuli. Targeted disruption of the fak gene in mice leads to death at embryonic day 8.5 (E8.5). FAK-/- embryos have severely impaired blood vessel development. Gene expression and in vitro differentiation studies revealed that endothelial cell...

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PMID: 12595342
DOI: 10.1161/01.res.0000055016.36679.23

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