Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming

1 Dec 2016

Abstract excerpt

Sexual reproduction culminates in a totipotent zygote with the potential to produce a whole organism. Sperm chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications generate a totipotent embryo. Active DNA demethylation of the paternal genome has been proposed to involve base excision and DNA repair-based mechanisms. The nature and consequence of DNA lesions generated during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pluripotent Stem Cells Research
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27916276
DOI: 10.1016/j.cell.2016.11.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic ReprogrammingPMID 27916276Read ↗

Epigenetics. Satellite tools.Semantic proximity Read ↗

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair PathwaySemantic proximity Read ↗

Genetic control of meiosis surveillance mechanisms in mammalsSemantic proximity Read ↗

Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosisSemantic proximity Read ↗

Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos.Semantic proximity Read ↗

Chromatin architecture reorganization in murine somatic cell nuclear transfer embryosSemantic proximity Read ↗

A genome-wide atlas of meiotic recombination intermediates reveals distinct modes of DNA repair that direct crossovers away from transcriptionally marked genesSemantic proximity Read ↗

Genome folding and zygotic genome activation in mammalian preimplantation embryosSemantic proximity Read ↗

Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse GermlineSemantic proximity Read ↗

Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguardSemantic proximity Read ↗

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair.Semantic proximity Read ↗

Offspring production of ovarian organoids derived from spermatogonial stem cells by chromatin reorganizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.