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Article

Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Miyoshi Norikatsu, Stel Jente M, Shioda Keiko, Qu Na, Odajima Junko, Mitsunaga Shino, Zhang Xiangfan, Nagano Makoto, Hochedlinger Konrad, Isselbacher Kurt J, Shioda Toshi

Abstract excerpt

The genome-wide depletion of 5-methylcytosines (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ cells (PGCs). Although recent studies have shown that in vitro differentiation of pluripotent stem cells (PSCs) to PGC-like cells (PGCLCs) mimics the...

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Identifiers

PMID: 27486249
DOI: 10.1073/pnas.1610259113
PMCID: PMC5003264

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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