Article

Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline

2020-06-17

Abstract excerpt

Germ cells specified during fetal development form the foundation of the mammalian germline. These primordial germ cells (PGCs) undergo rapid proliferation, yet the germline is highly refractory to mutation accumulation compared to somatic cells. Importantly, while the presence of endogenous or exogenous DNA damage has the potential to impact PGCs, there is little known about how these cells respond to stressors....

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Literature Corpus work: 11836cef-898e-5cdd-9340-a4acd95c7224
DOI: 10.1101/2020.06.16.155168

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