Article
On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study.
PLoS genetics - 17 Jun 2010
Paré Guillaume, Cook Nancy R, Ridker Paul M, Chasman Daniel I
Abstract excerpt
Testing for genetic effects on mean values of a quantitative trait has been a very successful strategy. However, most studies to date have not explored genetic effects on the variance of quantitative traits as a relevant consequence of genetic variation. In this report, we demonstrate that, under plausible scenarios of genetic interaction, the variance of a quantitative trait is expected to differ among the three...
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