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Article

An approach to identify gene-environment interactions and reveal new biological insight in complex traits.

Nature communications - 22 Apr 2024

Zhu Xiaofeng, Yang Yihe, Lorincz-Comi Noah, Li Gen, Bentley Amy R, de Vries Paul S, Brown Michael, Morrison Alanna C, Rotimi Charles N, Gauderman W James, Rao Dabeeru C, Aschard Hugues

Abstract excerpt

There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this issue, the Gene-Lifestyle Interactions Working Group within the Cohorts for Heart and Aging Research in Genetic Epidemiology Consortium has been spearheading efforts to...

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Identifiers

PMID: 38649715
DOI: 10.1038/s41467-024-47806-3
PMCID: PMC11035594

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